- Workshop: Mixed Models
Jos Twisk,
VU University Medical Center,
Department of Epidemiology and Biostatistics,
Amsterdam,
the Netherlands
In this workshop,
the basic concepts of mixed models will be explained with a special emphasis on the interpretation of the results of mixed model analyses.
The following topics will be discussed:
- Basic principles of mixed model analysis
- Background of mixed model analysis
- Example of a mixed model with a two level structure
- Example of a mixed model with a three level structure
- What do we gain by using mixed models
- The use of mixed model analysis in longitudinal studies
- Software
Furthermore,
at the end of the workshop there will be a short 'quiz' to evaluate whether the attendants of the workshop understood the theory and interpretation of mixed model analysis.
Jos Twisk studied human movement science in Amsterdam,
and after his graduation in 1990 he joined the research team of the Amsterdam Growth and Health Longitudinal Study (AGHLS).
In 1995,
he finished his PhD-thesis,
which was related to this longitudinal study and moved to the department of Epidemiology (the EMGO-Institute).
After his PhD,
he supervised several projects within the AGHSL and participated as a teacher and coordinator in several postdoctoral courses given at the EMGO-Institute.
In this period,
he specialised himself in the methodological field of longitudinal data analysis and multilevel analysis and wrote two textbooks about it (both published by Cambridge University Press).
In 2005,
he became a professor on applied biostatistics and head of the department of methodology and applied biostatistics at the Institute of Health Sciences.
He is now also head of the expertise centre of applied longitudinal data analysis.
His main activities are statistical and methodological consultancies,
teaching and applied methodological research.
- Seminar: Clinical epidemiology – Diederick E.
Grobbee
Diederick E.
Grobbee,
MD,
PhD,
FESC,
UMC Utrecht,
Julius Center for Health Sciences and Primary Care,
Utrecht,
the Netherlands
In the current era of evidence-based medicine,
clinical epidemiology is increasingly being recognized as an important tool in the critical appraisal of available evidence and the design of new studies.
Epidemiologic principles and methods provide and invaluable tool for applied clinical research.
In the seminar the main aspects of clinical epidemiologic study design will be addressed,
including the principles of diagnostic and prognostic research.
In an interactive session,
examples will be discussed and published literature will be analyzed.
Diederick Grobbee is Professor of Clinical Epidemiology at the University Medical Center Utrecht and chair of the Julius Center for Health Sciences and Primary Care.
He obtained an MD at the Utrecht University and a PhD in Epidemiology at Erasmus University,
Rotterdam.
After a residency in Internal Medicine,
he was appointed Associate Professor and subsequently full Professor of Clinical Epidemiology at Erasmus University.
He was a Visiting Associate Professor at Harvard School of Public Health,
Boston and is a Visiting Professor of Epidemiology and Medicine at Sydney University.
He is a member of the Royal Dutch Academy of Arts and Sciences,
board member of the Netherlands Heart Foundation and board member of the Academic Alliance for Clinical Trials.
He is a past president of the Netherlands Epidemiological Association.
At Utrecht University he directs the MSc and PhD programmes “Epidemiology”.
Diederick Grobbee has been on the editorial board of several journals and (inter)national scientific,
search and site-visit committees.
He is editor of the European Journal of Epidemiology and editor-in-chief of the European Journal for Cardiovascular Prevention and Rehabilitation.
Diederick Grobbee has been a (principal) investigator in many large scale epidemiologic studies and randomized trials of interventions for the prevention and treatment of cardiovascular diseases.
His experience covers the full range of epidemiologic study designs including trials,
cohorts and case-control studies.
Topics include hypertension,
diabetes,
risk factors in children and youngsters,
coronary heart disease,
women’s health,
cardiovascular ageing,
heart failure and non-invasive vascular imaging.
In addition to research on drugs he examined the cardiovascular effects of various nutrients and dietary factors in cohort studies and trials.
Apart from his interest in cardiovascular disease he has worked on the theoretical principles and methods of diagnostic and prognostic research and together with Arno W.
Hoes published the textbook “Clinical Epidemiology”(Boston,
Jones&Bartlett,
2009).
He supervised over 100 PhD fellows and published more than 800 scientific papers,
chapters and books.
Number of international citations (Google Scolar) 37860.
Hirsch: h = 98.
- Workshop: Methods of evaluation of cancer incidence and treatment effectiveness using cancer registries (moderators: Tapio Luostarinen,
Magdalena Bielska - Lasota)
1) Cancer predictions
Tadeusz Dyba,
Finnish Cancer Registry,
Institute for Statistical and Epidemiological Cancer Research,
Helsinki,
Finland
Dr.Tadeusz Dyba graduated from Cracow Economical University specialiazing in statistics and econometrics.
He worked as a statistician at Cracow Cancer Registry,
Karolinska Institute in Stockholm and,
after defending his doctoral thesis in statistics at Helsinki University as a scientist at Finnish Cancer Registry.
Dr.
Dyba has published 40 scientific publications in cancer epidemiology and biostatistics and is specialized in cancer incidence prediction.
2) Visualizing spatial-temporal variation of disease incidence
Eero Pukkala,
Finnish Cancer Registry,
Institute for Statistical and Epidemiological Cancer Research,
Helsinki,
Finland
Eero Pukkala is Director of Statistics and epidemiologist at the Finnish Cancer Registry,
Institute for Statistical and Epidemiological Cancer Research,
Helsinki.
He is Professor of Public Health and Epidemiology responsible for the EU international postgraduate education network “Speading of Excellence in Cancer Control using Population-Based Registries and Biobanks”,
member of the Scientific Committee on Emerging and Newly Identified Health Risks of the European Commission,
university lecturer and visiting professor in the University of Tampere.
He has been an initiator,
coordinator,
participant of steering committee or national principal investigator in tens of international scientific studies and study programmes
He has published more than 500 peer-reviewed epidemiological publications,
including studies on cancer and other health outcomes related to physical and social environment,
occupational hazards,
and life habits,
works on biological risk factors of cancer; familial clustering of cancer; evaluations of the effects of screenings and other interventions,
survival studies,
cancer predictions,
cancer map presentations for numerous countries and methodological publications on register and biobank data quality,
data protection or privacy issue (H – index exceeded 50 in Summer 2008).
3) Applications of cancer registry data in cancer control
Michel Coleman,
London School of Hygiene and Tropical Medicine,
London,
UK
Michel Coleman has been Professor of Epidemiology and Vital Statistics at the London School of Hygiene & Tropical Medicine since 1995.
He was Deputy Chief Medical Statistician at the Office for National Statistics from 1995 to 2004 and Head of the Cancer and Public Health Unit at the School from 1998 to 2003.
He has previously worked for the World Health Organisation at the WHO's International Agency for Research on Cancer in Lyon (1987-1991),
and was Medical Director of the Thames Cancer Registry in London (1991-1995).
The interests of Dr.
Coleman are trends in cancer incidence,
mortality and survival,
and the application of these tools to the public health control of cancer.
He has published over 200 articles on these topics,
including “Cancer survival in five continents: a worldwide population-based study (CONCORD)”,
the first worldwide analysis of cancer survival,
with standard quality-control procedures and identical analytic methods for all datasets.
CONCORD provides survival estimates for 1.9 million adults (aged 15-99 years) diagnosed with a first,
primary,
invasive cancer of the breast (women),
colon,
rectum,
or prostate during 1990-94 and followed up to 1999,
using individual tumour records from 101 population-based cancer registries in 31 countries on five continents.
- Precongress satellite meeting of the Reproductive Outcome and Migration (ROAM) international collaboration
Reproductive Outcomes And Migration (ROAM): An international research collaboration was established in August 2005 and currently consists of 33 researchers from 13 countries.
All collaboration members are self-selected researchers interested in migration and reproductive health.
Although all aspects of migrant women’s reproductive health are of interest to ROAM,
the collaboration has begun its work by focusing on perinatal health.
Some of the work of ROAM can be seen in upcoming or previously published articles (Small R,
Gagnon AJ, Gissler M,
Zeitlin J,
Bennis M,
Glazier R,
Haelterman E, Martens G,
Urquia M,
Vangen S.
Somali women and their pregnancy outcomes post-migration: data from six receiving countries.
British Journal of Obstetrics and Gynaecology. Dec 2008,
115(13): 1630-1640; Gissler M,
Alexander S,
Macfarlane A,
Small R,
Stray-Pedersen B,
Zeitlin J,
Zimbeck M,
Gagnon A for the ROAM collaboration. Stillbirths and infant deaths among migrants in industrialised countries.
Acta Obstetricia et Gynecologica Scandinavica 2009,
28: 134-148; Gagnon AJ,
Zimbeck M,
Zeitlin J and the ROAM collaboration. Migration to western industrialized countries and perinatal health: A systematic review.
Social Science and Medicine.
Accepted April 2009; Urquia M,
Glazier R,
Blondel B,
Zeitlin J,
Gissler M,
McFarlane A,
Ng E,
Heaman M,
Stray-Pedersen B,
Gagnon AJ. International Migration and Adverse Birth Outcomes: Role of Ethnicity,
Region of Origin and Destination.
Journal of Epidemiology and Community Health.
Accepted May 2009).
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